Synergistic Effects of Enriched Environment and Task-Specific Reach Training on Poststroke Recovery of Motor Function

Stroke; a Journal of Cerebral Circulation
Matthew Strider Jeffers, Dale Corbett

Abstract

Reach training in concert with environmental enrichment provides functional benefits after experimental stroke in rats. The present study extended these findings by assessing whether intensive task-specific reach training or enrichment initiated alone would provide similar functional benefit. Additionally, we investigated whether the 70% recovery rule, or a combined model of initial poststroke impairment, cortical infarct volume, and rehabilitation intensity, could predict recovery in the single-pellet task, as previously found for the Montoya staircase. Rats were trained on single-pellet reaching before middle cerebral artery occlusion via intracerebral injection of ET-1 (endothelin-1). There were 4 experimental groups: stroke+enrichment, stroke+reaching, stroke+enrichment+reaching, and sham+enrichment+reaching. Reaching rehabilitation utilized a modified Whishaw box that encouraged impaired forelimb reaching for 6 hours per day, 5 days per week, for 4 weeks. All treatment paradigms began 7 days after ischemia with weekly assessment on the single-pellet task during rehabilitation and again 4 weeks after rehabilitation concluded. Rats exposed to the combination of enrichment and reaching showed the greatest improvement in pelle...Continue Reading

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Citations

Feb 23, 2019·Current Neurology and Neuroscience Reports·Steven R Zeiler
May 30, 2019·Neurorehabilitation and Neural Repair·Naohiko OkabeOsamu Miyamoto
Aug 9, 2019·Stroke; a Journal of Cerebral Circulation·David T Bundy, Randolph J Nudo
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Jan 13, 2021·Stroke; a Journal of Cerebral Circulation·Kathryn S HaywardJulie Bernhardt
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May 7, 2021·Neurorehabilitation and Neural Repair·Scott R DeBoerSteven R Zeiler
Aug 28, 2021·Neurorehabilitation and Neural Repair·Michelle BroderickPaul Bentley

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