PMID: 893737Aug 1, 1977

Synergistic effects of hydralazine and alpha- or beta-adrenergic blockers: the role of plasma renin activity

Journal of Clinical Pharmacology
M GutkinR S Modlinger

Abstract

Intravenous hydralazine, 0.15, 0.30 or 0.60 mg/kg, was administered to 11 supine hypertensives on two occasions: once after pretreatment with intravenous propranolol, 0.1 mg/kg, and once after pretreatment with intravenous placebo. The average fall in mean arterial pressure for each dosage of hydralazine was no different with or without propranolol, even though propranolol inhibited rises in plasma renin activity and pulse due to hydralazine. However, in each of four patients who had high supine baseline plasma renin activity, propranolol enhanced the fall in blood pressure caused by hydralazine. A second group of patients was given an infusion of 0.01 or 0.02 mg/kg per minute phentolamine, which did not change baseline blood pressure. Subsequent administration of intravenous hydralazine, 0.15 mg/kg, resulted in a fall in blood pressure which was larger than previously observed with intravenous hydralazine alone, regardless of supine baseline plasma renin activity. These data are consistent with the hypothesis that reflex catecholamine release interferes with the hypotensive effect of intravenous hydralazine. Pretreating with propranolol weakens homeostatic defenses against hydralazine such as rises in pulse rate and plasma ren...Continue Reading

Citations

Jun 1, 1976·Circulation·W J MroczekF A Finnerty
Mar 27, 1975·The New England Journal of Medicine·D H StreetenT G Dalakos
Jun 5, 1975·The New England Journal of Medicine·W A Pettinger, H C Mitchell
Dec 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R S ModlingerM Gutkin
Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·R S Modlinger, M Gutkin
May 1, 1974·Kidney International·A MimranN K Hollenberg
Sep 1, 1969·The Journal of Clinical Endocrinology and Metabolism·N WinerA D Freedman
May 1, 1973·British Heart Journal·P A MajidS H Taylor
Sep 1, 1971·The American Journal of Cardiology·R SannerstedtL Werkö
Sep 1, 1966·The American Journal of Cardiology·I BrickI C Roddie
May 1, 1967·British Journal of Pharmacology and Chemotherapy·H BrunnerM Meier

Related Concepts

Z-Max
Diastolic Blood Pressure
Hypertensive Disease
Sodium
Pulse Taking
Drug Augmentation
REN
Rexigen
Nepresol
Preprorenin

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