PMID: 10447554Aug 14, 1999Paper

Synergistic effects of some metals contaminating mussels on the cytotoxicity of the marine toxin okadaic acid

Archives of Toxicology
Adama TraoréEdmond Ekué Creppy


Okadaic acid (OA), a marine toxin is cytotoxic and promotes tumours in mouse skin. It is a specific and potent inhibitor of protein synthesis and also inhibits phosphatases A1 and A2 in vitro. In the present study, we investigated the influence of metals found at acceptable levels in mussels as environmental pollutants on the cytotoxicity of OA in Vero cells. Among the metals found in mussels (Mytilus edulis), the most represented, in terms of molar quantities per gram of dried weight are aluminium (230 nmol/g), copper (58 nmol/g), lead (16 nmol/g), mercury (14 nmol/g) and cadmium (7.4 nmol/g). A solution containing these five metals Al(3+), Cu(2+), Pb(2+), Hg(2+) and Cd(2+) combined at the concentrations detected in mussels, stimulated protein synthesis (+25%, P < 0.01), whereas different dilutions of this solution in the presence of okadaic acid (15 ng/ml, i.e. 18.7 x 10(-9) M) increased the percentage of protein synthesis inhibition from 35 to 79%. The metals also increased the lactate dehydrogenase (LDH) release into the medium and the lipid peroxidation induced by this algal toxin. In addition, these metals reduced the cell viability for an incubation period of 24 h especially at the two higher concentrations. These result...Continue Reading


Dec 31, 2002·Toxicology·Edmond Ekué CreppyMaria-Rosaria Carratú
Apr 26, 2003·Journal of Toxicology and Environmental Health. Part a·Dimitrios L KalpaxisMaria Papapetropoulou
Sep 19, 2009·Toxicon : Official Journal of the International Society on Toxinology·John A KalaitzisBrett A Neilan
Jun 14, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·I ValverdeA G Cabado
Sep 2, 2005·Toxicon : Official Journal of the International Society on Toxinology·Jorge LagoAna G Cabado
Aug 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cheng ChiSe Chang Park

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