Synergistic efficacy of γ-radiation together with gallium trichloride and/or doxorubicin against Ehrlich carcinoma in female mice

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Eman Kandil, Nahed Abdel Aziz

Abstract

Combining chemotherapy with radiotherapy represents a key oncology strategy for a more comprehensive attack toward cancers and improves treatment outcome for various solid tumor malignancies. The present study aims to evaluate the synergistic antitumor effect of γ-radiation together with gallium trichloride (GaCl3) and/or doxorubicin (DOX) against solid Ehrlich carcinoma (EC) in female mice. GaCl3 (300 mg/kg body weight (b.w.)) was administered by gavages daily on the seventh day after tumor inoculation, while the cytotoxic drug DOX (4 mg/kg b.w.) was administered intraperitoneally once a week. Whole-body γ-radiation was carried out at a dose 2 Gy once a week. Biochemical analysis showed that solid EC induced a significant increase in malondialdehyde (MDA) content with a significant decrease in the antioxidant state (glutathione peroxidase (GPx) and catalase (CAT) activities) and depleted serum iron concentration compared to normal control. Moreover, a significant increase was observed in calcium level and caspase-3 concentrations in both serum and tumor homogenate respectively associated with a significant alteration in heart, liver, and kidney functions, as compared to control. Treatment of EC-bearing mice with GaCl3and/or DO...Continue Reading

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Citations

Mar 29, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Eman I KandilOla Ms Khedr
Oct 13, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Amina M MedhatNermeen M El Bakary
Jun 5, 2020·Integrative Cancer Therapies·Ghada A El TawiilHebatallah E Mohamed
Aug 24, 2019·Current Medicinal Chemistry·Lozan TodorovMaria Traykova

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