Synergistic functions of phorbol ester and calcium in serotonin release from human platelets

Biochemical and Biophysical Research Communications
J YamanishiY Nishizuka

Abstract

In human platelets, thrombin activates Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C) and mobilizes Ca2+ concomitantly, whereas 12-O-tetradecanoylphorbol-13-acetate (TPA) may be intercalated into membranes and directly activates protein kinase C without mobilization of Ca2+ in sufficient quantities. A series of experiments with TPA and Ca2+-ionophore (A23187) indicates that activation of protein kinase C is a prerequisite requirement for release of serotonin, and that this enzyme activation and Ca2+ mobilization act synergistically to elicit a full cellular response. Both cyclic AMP and cyclic GMP inhibit activation of protein kinase C by prohibiting the signal-dependent breakdown of inositol phospholipid to produce diacyl-glycerol, but none of these cyclic nucleotides prevents the TPA-induced activation of this enzyme.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D R Hathaway, R S Adelstein
Oct 1, 1975·The Journal of Clinical Investigation·R M LyonsP W Majerus
Nov 1, 1978·Journal of Virology·K Beemon, T Hunter
Apr 1, 1979·The Journal of Clinical Investigation·S Rittenhouse-Simmons
May 29, 1975·Nature·J L Costa, D L Murphy
Jan 1, 1974·Methods in Enzymology·N L Baenziger, P W Majerus
Jan 15, 1982·Biochemical and Biophysical Research Communications·K KaibuchiA Ichihara
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J E NiedelG R Vandenbark
Nov 17, 1980·Biochemical and Biophysical Research Communications·Y KawaharaY Nishizuka
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

❮ Previous
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Citations

Dec 1, 1989·Journal of Cellular Physiology·T C Chan
Oct 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·A R WakadeT D Wakade
Sep 1, 1988·Cellular and Molecular Neurobiology·R W Holz
Oct 1, 1994·Cardiovascular Drugs and Therapy·K E Torfgård, J Ahlner
Jan 1, 1991·Neurochemical Research·G Shanker, H J Baker
Aug 1, 1990·The Journal of Membrane Biology·T Wang, Y L Chan
Jun 27, 1986·Biochimica Et Biophysica Acta·L G DobbsS Hawgood
Apr 15, 1988·Biochimica Et Biophysica Acta·F D Lytton, M D Mitchell
Jun 15, 1984·Biochemical and Biophysical Research Communications·Y KatakamiY Nishizuka
May 1, 1990·Developmental Biology·J D DavidG P Perrot
Mar 11, 1986·European Journal of Pharmacology·H MenkesS H Snyder
Mar 15, 1988·European Journal of Pharmacology·R V VegesnaS T Crooke
Jul 1, 1994·The International Journal of Biochemistry·D Bischof, K D Hammond
Feb 28, 1994·Behavioural Brain Research·W Q ZhaoK T Ng
Dec 8, 1993·Biochimica Et Biophysica Acta·J Gupta, R G Downer
Sep 14, 1984·Biochimica Et Biophysica Acta·R D Burgoyne, K M Norman
Nov 17, 1992·Biochimica Et Biophysica Acta·G M Anderson, W C Horne
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·M B Hansen, N Bindslev
Nov 1, 1985·Molecular and Cellular Endocrinology·D DelbekeP S Dannies
Sep 1, 1989·Molecular and Cellular Endocrinology·S DasG A Bourne
Jan 15, 1996·Molecular and Cellular Endocrinology·J P Liu
Sep 15, 1989·Biochimica Et Biophysica Acta·T F AbidiJ D Laskin
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R F AldersonE T Butler

❮ Previous
Next ❯

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