PMID: 6965307Jan 1, 1980Paper

Synergistic genetic defect in B-lymphocyte function. I. Defective responses to B-cell stimulants and their genetic basis

The Journal of Experimental Medicine
C BonaW E Paul

Abstract

CBA/N female mice, which express an X-linked defect in B-lymphocyte function, were mated with C3H/HeJ male mice, which are unresponsive to lipopolysaccharide (LPS). The resulting F1 hybrid females were mated to C3H/HeJ males. Approximately one-half of the backcross (BC.1) males obtained from this mating expressed a more profound immunologic defect than either of the parental strains. Spleen cells from these mice were unresponsive to a series of B-cell mitogens including LPS prepared from Escherichia coli K235 and from E. coli 0111:B4, lipoprotein mitogen from E. coli, and Nocardia water-soluble mitogen (NWSM). They failed to give in vitro antibody responses to the thymus-independent type 2 (TI-2) antigen trinophenylated Ficoll and most were unresponsive to the TI-1 antigens trinitrophenylated Brucella abortus, trinitrophenylated LPS, and trinitrophenylated NWSM. This synergistic defect in B-lymphocyte function depended on the presence of the CBA/N xid gene but the critical gene(s) from the C3H strain was not the defective Lps gene (Lpsd). These mice should provide a valuable tool for the elucidation of B-lymphocyte ontogeny, heterogeneity, and function.

References

Feb 1, 1977·The Journal of Experimental Medicine·P W Kincade
Jan 1, 1977·Immunological Reviews·D E MosierW E Paul
Nov 1, 1975·The Journal of Experimental Medicine·F D FinkelmanW E Paul

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Citations

Oct 3, 1999·European Journal of Immunology·D D PinschewerR M Zinkernagel
May 1, 1995·Molecular Immunology·K A BrorsonK E Stein
Aug 1, 1996·Current Opinion in Immunology·A B Satterthwaite, O N Witte
Mar 1, 1982·The Journal of Experimental Medicine·H H WortisG Waneck
Sep 9, 1998·The Journal of Experimental Medicine·A B SatterthwaiteO N Witte
May 17, 2000·The Journal of Experimental Medicine·U D BajpaiH H Wortis
Jan 1, 1996·Annual Review of Immunology·A Satterthwaite, O Witte
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·A B SatterthwaiteO N Witte
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·A B SatterthwaiteO N Witte
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·David A FrumanOwen N Witte
Mar 18, 2005·Annual Review of Immunology·Hassan JumaaMichael Reth
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark S CabatinganRobert T Woodland
Feb 1, 1985·Journal of Virology·M A RealeJ L Schulman

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