PMID: 7543378Aug 1, 1995Paper

Synergistic increase in chromosomal breakage within the euchromatin induced by an interaction of the benzene metabolites phenol and hydroquinone in mice

Carcinogenesis
H Chen, D A Eastmond

Abstract

The hematopoietic and carcinogenic effects of benzene may result from an interaction of various benzene metabolites. Following the co-administration of phenol and hydroquinone, a synergistic increase in myelotoxicity and genotoxicity has been observed in the bone marrow of mice. To understand the mechanisms underlying these synergistic genotoxic effects we have studied the origin of micronuclei (MN) formed in bone marrow erythrocytes following the co-administration of these two metabolites. Phenol and hydroquinone were administered to male CD-1 mice by i.p. injection three times at 24 h intervals. The frequency of MN was evaluated in bone marrow cells harvested 24 h following the final dose. A marked increase in MN was observed in mice co-administered phenol and hydroquinone, which was significantly greater than that observed with the individual metabolites. Labeling with the CREST antibody and multicolor fluorescence in situ hybridization with the mouse major and minor satellite probes indicated that both chromosomal loss and breakage and occurred. The major increase in MN induced by the phenol and hydroquinone combination originated from breakage in the euchromatic region of the mouse chromosomes. The origin of MN in mice co-...Continue Reading

Citations

Feb 4, 2005·Archives of Toxicology·Edgar Rivedal, Gisela Witz
May 29, 2004·Mutation Research·John WhysnerElizabeth A Lax
Dec 1, 1996·Environmental Health Perspectives·C E FrantzD A Eastmond
Jan 21, 2014·Environmental Toxicology and Pharmacology·Manas Kumar Mukhopadhyay, Debjani Nath
Jan 15, 2014·ISRN Toxicology·Priyanka MandaniHyacinth Highland
Nov 26, 2009·Chemico-biological Interactions·Edgar RivedalEdward Leithe
Jun 15, 2007·Journal of Biochemistry and Molecular Biology·Ali Turhan, Egemen Dere
Apr 24, 2001·Environmental and Molecular Mutagenesis·C R GiverM G Pallavicini
Aug 19, 2017·International Journal of Environmental Research and Public Health·Adriana NowakBeata Gutarowska
Aug 9, 2001·American Journal of Industrial Medicine·R B HayesM Linet
Dec 17, 1997·Toxicology and Industrial Health·G L Gist, J R Burg
Nov 21, 2007·Critical Reviews in Toxicology·Douglas McGregor
Jan 1, 2008·Biomarker Insights·Han-Jin ParkS V S Rana
Dec 12, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura

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