PMID: 8785021Jan 1, 1995

Synergistic interactions between COMT-/MAO-inhibitors and L-Dopa in MPTP-treated mice

Journal of Neural Transmission. General Section
A Fredriksson, T Archer


Four experiments were performed to investigate the anti-akinesia effects of combining a sub-threshold dose (5 mg/kg, s.c.) of L-Dopa with different doses and combinations of COMT and MAO inhibitors upon the hypokinesia observed in MPTP-treated mice. Ro 40-7592 (1 and 3 mg/kg, s.c.), a novel COMT inhibitor, 60 min before L-Dopa reinstated both locomotion and rearing during a 2-hr interval after L-Dopa in MPTP mice; control mice were unaffected. The combination of Ro 40-7592 (3 mg/kg, s.c.) and pargyline (5 mg/kg, s.c.), a MAO inhibitor, with L-Dopa produced increases in both the peak effect and duration of action indicating a distinct potentiation of the effects of Ro 40-7592 by pargyline. L-Deprenyl, a MAOB inhibitor, together with L-Dopa, restored locomotion and rearing behaviour at all three doses applied (1, 3 and 10 mg/kg, s.c.); in control mice, motor activity was stimulated at the higher doses (3 and 10 mg/kg, s.c.), independent of L-Dopa administration. Combining L-Deprenyl (3 mg/kg, s.c.) with Ro 40-7592 (3 mg/kg, s.c.) one hr before L-Dopa to MPTP mice potentiated the restorative effects of each compound by itself, although no increase in peak effect was obtained. In the control mice, L-Deprenyl plus Ro 40-7592 or L-De...Continue Reading


Oct 15, 1977·Lancet·A J LeesM B Youdim
Dec 1, 1978·British Journal of Clinical Pharmacology·G P ReynoldsG M Stern
Jan 1, 1978·Journal of Neural Transmission·J Knoll
Jan 1, 1978·Journal of Neural Transmission·U K RinneV Sonninen
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·C OkudaR Kuczenski
Jan 1, 1991·Acta Neurologica Scandinavica. Supplementum·E H Heinonen, R Lammintausta
Nov 1, 1991·Acta Neurologica Scandinavica·M H Hietanen
Aug 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M Da Prada
Jan 1, 1990·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·J MajJ Superata
Oct 1, 1990·Pharmacology & Toxicology·A FredrikssonT Archer
Jan 1, 1990·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·P T MännistöS Kaakkola
Apr 1, 1990·Acta Neurologica Scandinavica·H Teräväinen
May 1, 1990·Pharmacology & Toxicology·P T Männistö, S Kaakkola
Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·I J MitchellA R Crossman
Jan 1, 1989·Acta Neurologica Scandinavica. Supplementum·J Knoll
Jan 1, 1989·Acta Neurologica Scandinavica. Supplementum·E H HeinonenU K Rinne
Sep 1, 1989·Pharmacology, Biochemistry, and Behavior·F B WeihmullerJ P Bruno
Jan 1, 1987·Journal of Neural Transmission·J NuutilaP T Männistö
Feb 1, 1986·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T YoshidaY Kuroiwa
Oct 7, 1986·European Journal of Pharmacology·P K Sonsalla, R E Heikkila
Jun 1, 1987·Annals of Neurology·J G NuttD Merrick
Feb 20, 1971·Lancet·A Barbeau
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·N S SharplessC A Owen
Jan 1, 1983·Modern Problems of Pharmacopsychiatry·W BirkmayerM B Youdim
Mar 1, 1983·Neurology·J J GervasJ G de Yébenes
Jul 1, 1981·Pharmacology, Biochemistry, and Behavior·R E HeikkilaR C Duvoisin
Mar 1, 1982·Italian Journal of Neurological Sciences·A ColomboM Gibertoni
Sep 1, 1982·Annals of Neurology·A Reches, S Fahn
Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·A Fredriksson, T Archer
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·J TimárJ Knoll
Jul 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·M GuttmanA Gjedde


Apr 29, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·E A BudyginP T Männistö
Jun 22, 2006·Neurotoxicity Research·T Archer, A Fredriksson
Oct 9, 1998·Journal of Neuroscience Methods·G RozasJ L Labandeira-García
Oct 30, 2001·Behavioural Brain Research·M SedelisJ P Huston
Mar 15, 2001·Parkinsonism & Related Disorders·A FredrikssonT Archer
Jul 25, 2013·Neuroscience Letters·Rachanee ChanasongSutisa Nudmamud-Thanoi
Dec 11, 2007·The Journal of Pharmacology and Experimental Therapeutics·Eric C K Siu, Rachel F Tyndale
Nov 21, 2019·Expert Opinion on Drug Discovery·Kalliopi MoschovouAntreas Afantitis

Related Concepts

Behavior, Animal
Dose-Response Relationship, Drug
Drug Augmentation
Enzyme Inhibitors
Mice, Inbred C57BL
RIMA (Reversible Inhibitor of Monoamine Oxidase A)

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.