Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals

Biochemical Pharmacology
L Clejan, A I Cederbaum

Abstract

The toxicity associated with paraquat is believed to involve the generation of active oxygen radicals and the production of oxidative stress. Paraquat can be reduced by NADPH-cytochrome P-450 reductase to the paraquat radical; this results in consumption of NADPH. A variety of ferric complexes, including ferric-ATP, -citrate, -EDTA, ferric diethylenetriamine pentaacetic acid and ferric ammonium sulfate, produced a synergistic increase in the paraquat-mediated oxidation of NADPH. This synergism could be observed with very low concentrations of iron, e.g. 0.25 microM ferric-ATP. Very low rates of hydroxyl radical were generated by the reductase with paraquat alone, or with ferric-citrate or -ATP or ferric ammonium sulfate in the absence of paraquat; however, synergistic increases in the rate of hydroxyl radical generation occurred when these ferric complexes were added together with paraquat. Ferric-EDTA and -DTPA catalyzed some production of hydroxyl radicals, which was also synergistically elevated in the presence of paraquat. Ferric desferrioxamine was essentially inert in the absence or presence of paraquat. This enhancement of hydroxyl radical generation was sensitive to catalase and competitive scavengers but not to superox...Continue Reading

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N R BachurH Kon
Jan 1, 1978·Methods in Enzymology·A G HildebrandtG Heinemeyer
Aug 1, 1976·Environmental Health Perspectives·J S BusJ E Gibson
Jan 1, 1985·Free Radical Research Communications·R Kohen, M Chevion
May 15, 1985·Biochemical Pharmacology·R Kohen, M Chevion
Jun 1, 1985·Chemico-biological Interactions·M YounesC P Siegers
Jun 4, 1974·Biochemical and Biophysical Research Communications·J S BusJ E Gibson
Nov 15, 1984·Archives of Biochemistry and Biophysics·H C Sutton, C C Winterbourn
Jul 6, 1981·FEBS Letters·R J Youngman, E F Elstner
Apr 1, 1984·The Biochemical Journal·B Halliwell, J M Gutteridge
Jan 1, 1984·Methods in Enzymology·A I Cederbaum, G Cohen
Oct 31, 1983·Biochemical and Biophysical Research Communications·D E Feierman, A I Cederbaum
Nov 15, 1984·Archives of Biochemistry and Biophysics·D R KoopM J Coon
Jan 1, 1983·Biochemical Pharmacology·E CadenasH Sies
Sep 15, 1981·Toxicology and Applied Pharmacology·M A TrushT E Gram

❮ Previous
Next ❯

Citations

Oct 15, 1995·Journal of Neuroscience Research·T FukushimaY Yamane
Jan 1, 1994·Archives of Toxicology·M Tomita, T Okuyama
Jul 8, 2011·Neurotoxicity Research·Li Rebekah Feng, Kathleen A Maguire-Zeiss
Jan 1, 1991·Free Radical Biology & Medicine·G H WolfgangT W Petry
Nov 25, 2000·Aquatic Toxicology·C VismaraR Bacchetta
Sep 12, 2001·Aquatic Toxicology·C VismaraU Fascio
Sep 6, 2003·Alcohol·Arthur I Cederbaum
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·B J DayJ S Stamler
Aug 8, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R J Dinis-OliveiraA Sánchez Navarro
May 14, 2005·Antioxidants & Redox Signaling·Xue-Fei WuJau-Shyong Hong
May 14, 2005·Antioxidants & Redox Signaling·Serge Przedborski, Harry Ischiropoulos
Sep 22, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Derek A Drechsel, Manisha Patel
Jul 1, 2002·Environmental Health and Preventive Medicine·Tetsuhito FukushimaMasaki Moriyama
Mar 11, 2010·Journal of Clinical Biochemistry and Nutrition·Kumi KimuraAsako Takenaka
Apr 5, 2011·Parkinson's Disease·P C KeaneC M Morris
Mar 10, 2015·Journal of Neural Transmission·Pamela Lopert, Manisha Patel
Dec 31, 2011·Free Radical Biology & Medicine·A A BrimfieldJ S Graham
Oct 1, 1993·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T FukushimaY Yamane
Dec 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T FukushimaY Yamane
Dec 23, 2008·Biochimica Et Biophysica Acta·Andrew J Ghio
May 28, 2011·British Journal of Clinical Pharmacology·Indika B Gawarammana, Nicholas A Buckley
Mar 26, 2005·Brain Research. Molecular Brain Research·Dafna Bonneh-BarkayDonato A Di Monte
Jul 1, 1992·Toxicology and Applied Pharmacology·V SrikrishnaN A Monteiro-Riviere
Feb 13, 2008·Journal of Neurochemistry·Qingyan Fei, Douglas W Ethell
Jun 15, 2010·Chemico-biological Interactions·Rodrigo FrancoMihalis I Panayiotidis
Oct 4, 2006·Free Radical Biology & Medicine·R J Dinis-OliveiraF Carvalho
Sep 15, 1992·Biochemistry·F Centeno, C Gutiérrez-Merino
Dec 15, 2006·Neurobiology of Disease·Maya G PurisaiDonato A Di Monte
Jul 4, 2006·Neurotoxicology·R J Dinis-OliveiraF Carvalho
Oct 24, 2017·Nature Chemical Biology·Colleen R ReczekNavdeep S Chandel
Jan 17, 2017·Human & Experimental Toxicology·R M SatputeP D Ambhore
May 25, 2004·The Journal of Biological Chemistry·Jun PengJulie K Andersen
Dec 29, 2007·Critical Reviews in Toxicology·R J Dinis-OliveiraF Carvalho
May 4, 2018·Biomedit︠s︡inskai︠a︡ khimii︠a︡·A V KuzikovV V Shumyantseva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.