PMID: 7514683Jun 1, 1994Paper

Synergistic neutralization of human immunodeficiency virus type 1 by combinations of human monoclonal antibodies

Journal of Virology
S LaalSusan Zolla-Pazner

Abstract

The ability of antibodies to the V3 region and the CD4-binding domain (CD4bd) of human immunodeficiency virus type 1 (HIV-1) to act in synergy to neutralize HIV has been demonstrated previously. However, synergy between antibodies to other HIV-1 epitopes has not been studied. We have used 21 combinations of human monoclonal antibodies (MAbs) directed against different epitopes of the gp120 and gp41 proteins of HIV-1 to evaluate their ability to act in synergy to neutralize HIV-1. Combinations of anti-V3 and anti-CD4bd antibodies, anti-V3 and anti-gp120 C-terminus antibodies, anti-CD4bd and anti-C-terminus antibodies, anti-V3 and anti-gp41 antibodies, and anti-CD4bd and anti-gp41 antibodies were tested. Our results show that some, but not all anti-V3 antibodies can act in synergy with anti-CD4bd antibodies. In addition, for the first time, antibodies to the C-terminus region have been found to act in synergy with the anti-CD4bd antibodies. Various anti-CD4bd MAbs also act in synergy when used together. The use of such cocktails of human MAbs for passive immunization against HIV-1 may prove to be important for therapy in postexposure settings and for prevention of maternal-fetal transmission of the virus. The results also provide...Continue Reading

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Citations

Sep 1, 1995·AIDS Research and Human Retroviruses·D N ForthalW E Robinson
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E O HochleitnerK B Tomer
Sep 20, 2001·The Journal of General Virology·J L Martínez-TorrecuadradaJ I Casal
Jun 1, 1995·AIDS Research and Human Retroviruses·A R NeurathS Jiang
Dec 1, 1995·AIDS Research and Human Retroviruses·S Zolla-Pazner, S Sharpe
Jan 1, 1996·Annual Review of Microbiology·G Pantaleo, A S Fauci
Sep 1, 2013·Pediatria polska·Leonard BothAnthony R Fooks
Apr 14, 2017·Cell Reports·Katie A HowellM Javad Aman
Sep 20, 2002·Journal of Virology·Ting-Chao Chou

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