Synergistic neutralizing activities of antibodies to outer membrane proteins of the two infectious forms of vaccinia virus in the presence of complement

Virology
Shlomo LustigBernard Moss

Abstract

The two forms of infectious vaccinia virus particles, known as intracellular mature virions and extracellular enveloped virions, are liberated by cell lysis and exocytosis, respectively. The extracellular enveloped form, which is highly resistant to antibody neutralization, contains an outer membrane surrounding an intracellular mature form. We provide evidence that complement mediates antibody-dependent lysis of the outer membrane of extracellular virus, exposing the inner infectious virus to neutralization by a second antibody. These results can help explain the disparity between the in vitro neutralizing and in vivo protective effects of antibodies to extracellular envelope proteins as well as the enhanced protection afforded by specific combinations of antibodies.

References

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Citations

Mar 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hua-Poo SuDavid N Garboczi
Sep 29, 2006·Journal of Virology·Jie TangPhyllis Flomenberg
Nov 21, 2008·Journal of Virology·Mohammed Rafii-El-Idrissi BenhniaShane Crotty
Dec 15, 2010·Journal of Virology·Johan LanttoAllan Jensen
Feb 12, 2011·Antiviral Therapy·Yoshiaki TomimoriShane Crotty
Mar 12, 2010·Expert Review of Vaccines·Nir Paran, Shlomo Lustig
Oct 14, 2009·Vaccine·Juan E Moyron-QuirozShane Crotty
Jul 11, 2006·Immunological Reviews·Ian J AmannaShane Crotty
Jan 5, 2011·Immunological Reviews·Bernard Moss
Sep 4, 2013·The Journal of General Virology·Geoffrey L SmithRebecca P Sumner

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