Synergistic oxidative impact of aluminum chloride and sodium fluoride exposure during early stages of brain development in the rat

Environmental Science and Pollution Research International
Amal A Kinawy

Abstract

Aluminum is widely used in industry and in cooking utensils, especially in countries with low economic and social standards. Fluoride is also used in industry, a major component of toothpaste and is added to the drinking water in many countries to fight teeth decay and cavities. Consequently, the coexistence of aluminum and fluoride is highly probable. Growing evidence indicates that environmental pollutants during the early stages of embryonic development may reprogram the offspring's brain capabilities to encounter oxidative stress during the rest of their postnatal life. This study investigated the impact of sodium fluoride (NaF, 0.15 g/L) and aluminum chloride (AlCl3, 500 mg/L) added, individually or in combination, to the deionized drinking water starting from day 6 of gestation until just after weaning, or until the age of 70 days postnatal life. A significant decline was observed in tissue contents of vitamin C, reduced glutathione, GSH/GSSH ratio, and the total protein, as well as in the activities of Na+/K+-ATPase and superoxide dismutase (SOD) in almost all cases. On the contrary, lipid peroxidation and NO, as total nitrate, exhibited a significant increase in comparison with the corresponding control. Based on the pr...Continue Reading

References

Aug 10, 1991·Lancet·L C Neri, D Hewitt
Apr 1, 1990·Trends in Biochemical Sciences·J M Gutteridge, B Halliwell
May 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B Fulton, E H Jeffery
Jan 31, 1972·Biochemical and Biophysical Research Communications·M NishikimiK Yagi
May 23, 1998·Neurochemistry International·J L Cadet, C Brannock
Feb 17, 2000·Neurochemistry International·C B PocernichD A Butterfield
Jan 4, 2001·Journal of Exposure Analysis and Environmental Epidemiology·L R O'FallonA Dearry
Feb 28, 2001·Experimental Gerontology·M Kasapoglu, T Ozben
Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Domenico PraticòVirginia M-Y Lee
Sep 3, 2003·Journal of Neurochemistry·D Allan ButterfieldAlessandra Castegna
Feb 1, 2005·Biochimica Et Biophysica Acta·D Allan Butterfield, Debra Boyd-Kimball
Nov 26, 2005·Journal of Alzheimer's Disease : JAD·Masahiro Kawahara
Dec 6, 2005·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Bimla Nehru, Priya Anand
Mar 15, 2006·World Journal of Gastroenterology : WJG·Ling-Fei He, Jian-Gang Chen
Dec 27, 2006·Journal of Ethnopharmacology·Amar JyotiDeepak Sharma
Jun 6, 2009·Biological Trace Element Research·Madhusudhan Narayanaswamy, Mahaboob Basha Piler
Jun 23, 2009·Drug and Chemical Toxicology·Tanzeer KaurBimla Nehru
Jun 23, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hanaa A Hassan, Mokhtar I Yousef
Jul 24, 2010·Chemico-biological Interactions·Olivier BarbierLuz María Del Razo
Dec 21, 2010·Environmental Science & Technology·Larry L NeedhamPal Weihe
Apr 1, 2003·Environmental Toxicology and Pharmacology·Guoyan LiuLi Cui
Sep 1, 2009·Environmental Toxicology and Pharmacology·Ruiyan NiuJundong Wang
Apr 26, 2012·Bulletin of Environmental Contamination and Toxicology·Seyed Fazel NabaviSeyed Mohammad Nabavi
Dec 3, 2014·Neurotoxicology and Teratology·Anna L ChoiPhilippe Grandjean
Nov 5, 2016·Perspectives in Public Health·Chitta R ChowdhuryMartin Grootveld
Oct 28, 2016·Biological Trace Element Research·K DecI Gutowska
Jun 28, 2017·Interdisciplinary Toxicology·Chandra Shakar Reddy Nalagoni, Pratap Reddy Karnati

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Citations

Feb 20, 2020·Critical Reviews in Toxicology·N I Agalakova, O V Nadei
Sep 1, 2020·Biological Trace Element Research·Yugandhar P ReddyVarun Kumar Sharma

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