Abstract
Citrus aurantium L. is used in traditional medicine in India for treating stomach ache, vomiting, blood pressure, dysentery, diarrhea, cardiovascular analeptic, sedative, boils and urinary tract infections. Its essential oil from fruit peels has antioxidant, antimicrobial, antifungal, antiparasitic, and anti-inflammatory activities. The aim of the study was to characterize the antifungal activity and synergistic potential of essential oil extracted from leaves of Citrus aurantium L. of North-Western Himalayas against Candida albicans. Citrus aurantium essential oil (CAEO) was extracted from leaves and characterized by GC-MS. The antifungal activity and synergistic potential of CAEO against C. albicans was studied by agar well diffusion, and broth microdilution assay. The anti-fungal potential of the phytoconstituents of CAEO was studied by in silico interaction with two fungal drug targets, N-myristoyl transferase (NMT) and Cytochrome P450 14 Alpha-sterol Demethylase (CYP51). CAEO exhibited strong antifungal activity against two strains of C. albicans, with fungicidal effect. The MIC of CAEO against C. albicans strains was 0.15 - 0.31% (v/v). CAEO exhibited synergistic potential with fluconazole and amphotericin B against C. al...Continue Reading
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