Synergistic potential of Citrus aurantium L. essential oil with antibiotics against Candida albicans.

Journal of Ethnopharmacology
Prakriti NidhiAnuradha Sourirajan

Abstract

Citrus aurantium L. is used in traditional medicine in India for treating stomach ache, vomiting, blood pressure, dysentery, diarrhea, cardiovascular analeptic, sedative, boils and urinary tract infections. Its essential oil from fruit peels has antioxidant, antimicrobial, antifungal, antiparasitic, and anti-inflammatory activities. The aim of the study was to characterize the antifungal activity and synergistic potential of essential oil extracted from leaves of Citrus aurantium L. of North-Western Himalayas against Candida albicans. Citrus aurantium essential oil (CAEO) was extracted from leaves and characterized by GC-MS. The antifungal activity and synergistic potential of CAEO against C. albicans was studied by agar well diffusion, and broth microdilution assay. The anti-fungal potential of the phytoconstituents of CAEO was studied by in silico interaction with two fungal drug targets, N-myristoyl transferase (NMT) and Cytochrome P450 14 Alpha-sterol Demethylase (CYP51). CAEO exhibited strong antifungal activity against two strains of C. albicans, with fungicidal effect. The MIC of CAEO against C. albicans strains was 0.15 - 0.31% (v/v). CAEO exhibited synergistic potential with fluconazole and amphotericin B against C. al...Continue Reading

References

Jun 1, 1996·International Journal of Dermatology·W RamadanF Sonbol
Mar 27, 2001·Drug Discovery Today·A P. Li
Jun 23, 2001·The Journal of Antimicrobial Chemotherapy·J M Andrews
Jul 5, 2001·Cellular and Molecular Life Sciences : CMLS·P Anzenbacher, E Anzenbacherová
Dec 3, 2002·Nature Reviews. Genetics·Judith Berman, Peter E Sudbery
Dec 20, 2002·Journal of Computer-aided Molecular Design·Sean EkinsMaggie A Z Hupcey
Mar 4, 2003·Nature Reviews. Drug Discovery·Han van de Waterbeemd, Eric Gifford
Jun 1, 2005·Annals of Epidemiology·Robert A Halberstein
Apr 22, 2006·The EMBO Journal·Karla J DanielsDavid R Soll
Sep 5, 2006·ChemMedChem·Ulf Norinder, Christel A S Bergström
May 19, 2007·Medical Mycology·Joshua PerlrothBrad Spellberg
Nov 1, 2007·Nature Reviews. Drug Discovery·Paul D Leeson, Brian Springthorpe
May 27, 2010·Journal of Agricultural and Food Chemistry·Alfreda Wei, Takayuki Shibamoto
Jun 18, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A SaadL Hassani
Apr 8, 2011·Combinatorial Chemistry & High Throughput Screening·Tessy Geerts, Yvan Vander Heyden
Jan 10, 2012·Bioorganic & Medicinal Chemistry·Joachim PetitGerald Maggiora
Jun 1, 2010·Current Protocols in Pharmacology·Michael P Pollastri
Apr 4, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Imaël Henri Nestor Bassolé, H Rodolfo Juliani
Jun 28, 2016·Clinics in Dermatology·Jillian W Millsop, Nasim Fazel
Jan 17, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Mallappa Kumara SwamyUma Rani Sinniah
Feb 9, 2017·Frontiers in Microbiology·Liliana ScorzoniAna M Fusco-Almeida
May 10, 2018·Food Chemistry·Joycy Francely Sampaio Dos SantosMaria Flaviana Bezerra Morais-Braga
Feb 26, 2019·Frontiers in Plant Science·M Carmen González-MasAntonio Granell

❮ Previous
Next ❯

Citations

Jun 3, 2021·Journal of Fungi·Matthew Gavino DonaduClemencia Chaves-Lopez
Jul 10, 2021·Journal of Biomolecular Structure & Dynamics·Deeksha SalariaVikas Kumar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.