Synergistic Promotion on Tyrosinase Inhibition by Antioxidants

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yan WangZhen Yang

Abstract

When exposed to ultraviolet radiation, the human skin produces profuse reactive oxygen species (ROS), which in turn activate a variety of biological responses. Mounting ROS levels activate tyrosinase by mobilizing α-melanocyte-stimulating hormone in the epidermis and finally stimulates the melanocytes to produce melanin. Meanwhile, the Keap1-Nrf2/ARE pathway, which removes ROS, is activated at increased ROS levels, and antioxidant compounds facilitates the dissociation of Nrf2. In this study, we explored the possible suppressing effects of antioxidant compounds and tyrosine inhibitors on melanin formation and the promotory effects of these compounds on ROS scavenging. The antioxidant activity of glabridin (GLA), resveratrol (RES), oxyresveratrol (OXYR), and phenylethylresorcinol (PR) were investigated via the stable free radical 2,2-diphenyl-1-picrylhydrazyl method. The inhibitory effects of the four compounds and their mixtures on tyrosinase were evaluated. l-Tyrosine or 3-(3,4-dihydroxyphenyl)-l-alanine (l-DOPA) was used as a substrate. The results showed that all mixtures did not exhibit synergistic effects with the l-tyrosine as a substrate, suggesting that l-tyrosine is not suitable as a substrate. However, the mixtures of...Continue Reading

References

Jan 1, 1995·Contact Dermatitis·M NakagawaK Kawai
Mar 17, 1998·Biochemical and Biophysical Research Communications·N H ShinY Kim
Nov 25, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gerhard J NohynekHiroyuki Jinnai
Jun 18, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tamotsu TakizawaMasao Hirose
Jan 20, 2006·Pigment Cell Research·Ning Wang, Daniel N Hebert
Dec 15, 2006·Journal of Cosmetic Dermatology·W Westerhof, T J Kooyers
Apr 26, 2008·Photochemistry and Photobiology·Michaela Brenner, Vincent J Hearing
Jan 21, 2009·Cellular and Molecular Life Sciences : CMLS·H Y ParkB A Gilchrest
Feb 10, 2009·Molecular Nutrition & Food Research·Ji-Young BaeYoung-Hee Kang
Sep 9, 2009·Pigment Cell & Melanoma Research·Concepcion Olivares, Francisco Solano
Dec 23, 2011·Bioorganic & Medicinal Chemistry·Hiroki Satooka, Isao Kubo
Feb 7, 2012·Journal of Agricultural and Food Chemistry·Francesca GiampieriMaurizio Battino
Dec 5, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena KurinMilan Nagy
Jul 16, 2013·Fitoterapia·Charlotte SimmlerShao-Nong Chen
Mar 25, 2014·Bioorganic & Medicinal Chemistry·Christopher A Ramsden, Patrick A Riley
Apr 29, 2014·Bioorganic & Medicinal Chemistry Letters·Christopher A Ramsden, Patrick A Riley
Jun 18, 2014·Nature Chemical Biology·Vivek T NatarajanRajesh S Gokhale
Mar 3, 2015·Journal of Dermatological Science·Yoshiki TokuraTaisuke Ito
Apr 29, 2015·Free Radical Biology & Medicine·Matthias Schäfer, Sabine Werner
Jun 30, 2015·PloS One·Manpreet RandhawaEduardo Ruvolo
Sep 8, 2015·Current Pharmaceutical Biotechnology·You-Cheng HseuHui-Min D Wang
Sep 17, 2015·Interdisciplinary Sciences, Computational Life Sciences·Ganesh Prasad Mishra, Rajesh Sharma
Oct 10, 2015·IUBMB Life·Carmen Vanessa Ortiz-RuizFrancisco Garcia-Canovas
Nov 26, 2015·Journal of Dermatological Science·Qinghai ZengJianda Zhou
Jun 12, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jianmin ChenYufeng Huang
Sep 27, 2016·The British Journal of Dermatology·M A Birch-Machin, A Bowman
Feb 15, 2017·Indian Journal of Dermatology, Venereology and Leprology·Poonam PuriV Ramesh
May 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Roya Kolahdouz Mohammadi, Tahereh Arablou
May 24, 2017·Neurodegenerative Disease Management·Albena T Dinkova-Kostova, Aleksey G Kazantsev
May 28, 2017·Journal of Photochemistry and Photobiology. B, Biology·Ankit VermaRatan Singh Ray
Jul 12, 2017·Journal of Photochemistry and Photobiology. B, Biology·Denis Nchang CheSeon Il Jang
Aug 2, 2017·Oxidative Medicine and Cellular Longevity·Maya Ben Yehuda GreenwaldRon Kohen

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Citations

Sep 15, 2018·Journal of Cellular Biochemistry·Victoria BaryginaClaudia Fiorillo
Sep 10, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Zhiwei ShenYi Zhang
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Samaneh ZolghadriAli Akbar Saboury
Jul 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna Gaweł-BębenWirginia Kukula-Koch
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcelina Strzępek-GomółkaWirginia Kukula-Koch
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Askhat SabitovAgnieszka Ludwiczuk
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kittisak Likhitwitayawuid

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