Synergistic Radiation Dose Reduction by Combining Automatic Tube Voltage Selection and Iterative Reconstruction

Journal of Thoracic Imaging
Jeremy R WortmanAaron Sodickson

Abstract

The aim of the study was to evaluate radiation dose and image quality in computed tomographic pulmonary angiography (CTPA) scans performed with automatic tube voltage selection (ATVS, CarekV) before and after implementation of iterative reconstruction (IR, Safire). This IRB-approved study was conducted with waiver of informed consent. The cohort included 100 consecutive "standard protocol" CTPAs performed using ATVS and 100 consecutive "combined protocol" CTPAs performed using ATVS with a 33% reduction in reference mAs and IR. CTDIvol and main pulmonary artery enhancement, noise, and signal-to-noise ratio were recorded, along with blinded grading of subjective image quality. Dose and image quality were compared between cohorts with univariate analyses and linear regression models. The 33% reduction in reference mAs with the combined protocol allowed ATVS to select reduced kVp more often than with the standard protocol, with a reduction in 120 and 100 kVp scans (26% to 0% and 61% to 51%, respectively) and an increase in 80 kVp scans (13% to 49%). The combined protocol yielded a CTDIvol reduction of 43% (P<0.0001) and increases in main pulmonary artery enhancement (57 HU, P=0.005) and noise (P=0.019) with unchanged signal-to-nois...Continue Reading

References

Oct 26, 2005·AJR. American Journal of Roentgenology·Mark S ParkerNarinder N Sethi
Jul 25, 2006·AJR. American Journal of Roentgenology·Shigeki ItohTakeo Ishigaki
Mar 24, 2009·AJR. American Journal of Roentgenology·Richard T Griffey, Aaron Sodickson
Dec 17, 2009·Archives of Internal Medicine·Amy Berrington de GonzálezCharles Land
Nov 22, 2011·Radiologic Clinics of North America·Aaron Sodickson
Jun 12, 2012·Journal of Cardiovascular Computed Tomography·B Kelly HanJohn R Lesser
Jul 6, 2013·European Radiology·Tilo NiemannMartine Remy-Jardin
Jul 26, 2013·AJR. American Journal of Roentgenology·Mannudeep K KalraAnders Persson
Jul 26, 2013·AJR. American Journal of Roentgenology·Lifeng YuCynthia H McCollough
Nov 23, 2013·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hyun Joo ShinKi Whang Kim

❮ Previous
Next ❯

Software Mentioned

ATVS
CareBolus
JMP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.