PMID: 2484390Apr 1, 1989Paper

Synergistic toxicity between arsenic and methylated selenium compounds

Biological Trace Element Research
R J Kraus, H E Ganther

Abstract

Arsenite has been known for half a century to have a protective effect against selenium poisoning. Paradoxically, arsenite inhibits the conversion of inorganic selenium salts to methylated excretory products, although methylation has long been regarded as a detoxification mechanism for selenium. Moreover, there is evidence for a pronounced synergistic toxicity between arsenite and methylated selenium metabolites. We investigated the effect of arsenite on the acute toxicity of a variety of methylated or nonmethylated selenium compounds, as well as methylated forms of sulfur and tellurium. Adult male rats were injected with sodium arsenite (4 mg As/kg bw, s.c.) 10 min prior to injection of the test compounds; at the doses employed, none of the test compounds caused mortality, nor did arsenite, when given alone. When given with arsenite, the following methylated compounds produced toxic signs and high morality at the indicated dosages (mg Se/kg): Methylseleninic acid (2), dimethylselenoxide (2), trimethylselenonium chloride (3), selenobetaine (2), selenobetaine methylester (2, also 1 and 0.5), and Se-methylselenocysteine (2). Toxic signs but not mortality occurred when arsenite was given with selenomethionine (2 mg Se/kg). No enha...Continue Reading

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Citations

Jan 1, 1992·Archives of Environmental Contamination and Toxicology·D J HoffmanG W Pendleton
Aug 1, 1995·Biological Trace Element Research·E GlattreM Mysliveckova
Jun 27, 1997·Journal of Toxicology and Environmental Health·E M KenyonO A Levander
Sep 6, 2006·Journal of Toxicology and Environmental Health. Part a·Jadwiga PalusMaciej Stepnik
Apr 16, 1998·Environmental Health Perspectives·M A PerazaL T Rael
Apr 24, 2001·The Tohoku Journal of Experimental Medicine·Y XieM Chiba
May 24, 2014·Environment International·Hong-Jie SunLena Q Ma
Mar 27, 2001·Toxicology and Applied Pharmacology·M Styblo, D J Thomas
Jul 9, 2004·Critical Reviews in Toxicology·E DoppA V Hirner
Dec 8, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Emel KoseogluMurat Kendirci
Aug 28, 2009·Environmental Science & Technology·Roland A Diaz-Bone, Tom R van de Wiele
May 15, 1992·Journal of Inorganic Biochemistry·C Ip, H Ganther

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