PMID: 2485878Oct 23, 1989Paper

Synergy between a selective D1 antagonist and a selective D2 antagonist in the induction of catalepsy

Neuroscience Letters
S A ParashosT N Chase

Abstract

The cataleptogenic effects of the selective D1 dopamine receptor antagonist, SCH 23390, and the selective D2 dopamine receptor antagonist, raclopride, when administered alone or in combination were studied in rats using the vertical grid and horizontal bar methods. In either model both agents, given alone, produced dose-dependent catalepsy. When administered together, there was a marked synergy between the two drugs. Thus, a low dose of SCH 23390 resulted in a 10-fold shift to the left of the raclopride dose-effect curve. When the same low dose of SCH 23390 was administered together with a subcataleptogenic dose of raclopride, marked catalepsy was produced. The finding of synergy between selective D1 and D2 dopamine antagonists in the induction of catalepsy suggests that mixed antagonists may possess greater antipsychotic activity than neuroleptics acting mainly on one receptor subtype.

References

Jan 1, 1975·Pharmacology, Biochemistry, and Behavior·J MajB Przewlocka
Nov 5, 1985·European Journal of Pharmacology·M Morelli, G Di Chiara
Dec 1, 1985·Pharmacology, Biochemistry, and Behavior·W R Klemm
Apr 27, 1988·European Journal of Pharmacology·G H Fletcher, M S Starr
Jan 1, 1983·Annual Review of Neuroscience·I CreeseS E Leff

❮ Previous
Next ❯

Citations

Mar 1, 1996·Psychopharmacology·B J Kinon, J A Lieberman
Apr 1, 1996·Biulleten' eksperimental'noĭ biologii i meditsiny·R R Gaĭnetdinov, K S Raevskiĭ
Feb 9, 1993·European Journal of Pharmacology·E P PrinssenA R Cools
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·A Horita, M A Carino
May 1, 1993·Pharmacology, Biochemistry, and Behavior·C MarinT N Chase
Jul 16, 2003·European Journal of Pharmacology·Satoru NakaiTetsuro Kikuchi
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Renata C DutraMaria A B F Vital
Oct 17, 1998·Progress in Neurobiology·W Hauber
Nov 19, 2011·The International Journal of Neuropsychopharmacology·Tomek J Banasikowski, Richard J Beninger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here