Synergy between penicillin and gentamicin against enterococci

The Journal of Antimicrobial Chemotherapy
T G Winstanley, J G Hastings

Abstract

The role of active uptake in aminoglycoside activity against penicillin-treated enterococci was studied by viable counts and ATP determinations. Penicillin and gentamicin gave synergistic bactericidal and post-antibiotic effects (PAEs) which were partially reduced by sodium azide, an electron transport inhibitor, and totally blocked in the presence of both sodium azide and EDTA, which chelates divalent cations. EDTA and gentamicin showed marked synergy in both 'killing curve' and PAE experiments. This synergy was completely inhibited by sodium azide. The data indicate that the activity of gentamicin against enterococci that have been damaged by penicillin or EDTA is energy-dependent. This is consistent with present theories of gentamicin uptake via transportation drive by a protonmotive force.

Citations

Apr 6, 1999·APMIS. Supplementum·K Fuursted
Aug 7, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Christian S BetzAndreas Leunig
Jul 15, 2015·International Journal of Antimicrobial Agents·M RevestUNKNOWN Groupe de Réflexion sur les Infections de Prothèses vasculaires (GRIP)
May 23, 2018·Antimicrobial Agents and Chemotherapy·Autumn Brown GandtMichael D LaFleur

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