Synergy of antibiotics against Streptomyces somaliensis isolates in vitro

The Journal of Antimicrobial Chemotherapy
M A Nasher, R J Hay

Abstract

Eight dual antibiotic combinations were used to investigate possible synergic effects against different isolates of Streptomyces somaliensis. The antibiotic combinations that showed synergic activity against the isolates were, in decreasing order, fusidic acid-rifampicin, erythromycin-penicillin, erythromycin-fusidic acid, rifampicin-sulphamethoxazole, fusidic acid-sulphamethoxazole and erythromycin-rifampicin. Sulphamethoxazole-trimethoprim and rifampicin-trimethoprim combinations were not synergic against any of the S. somaliensis isolates tested.

Citations

Jan 31, 2009·Nature Reviews. Drug Discovery·Jia JiaYu Zong Chen
Jan 12, 2017·The Journal of Antibiotics·Kun LiXian-En Zhang
Mar 12, 2020·ACS Infectious Diseases·Declan Alan Gray, Michaela Wenzel

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