Synergy of iron in the toxicity and carcinogenicity of polychlorinated biphenyls (PCBs) and related chemicals

Toxicology Letters
Andrew G SmithS Madra

Abstract

In Ah-responsive C57BL/10ScSn mice a single dose of iron significantly potentiated the property of the polychlorinated biphenyl (PCB) mixture Aroclor 1254 to induce porphyria by inhibition at the uroporphyrinogen decarboxylase stage of hepatic haem biosynthesis. The induction of liver tumors and other lesions were also enhanced markedly by iron overload suggesting a link between porphyria and cancer. The cellular, molecular and biochemical processes involved have been investigated in attempts to explain these phenomena by an iron-catalysed 'oxidative stress' mechanism.

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Citations

Apr 5, 2005·Journal of Toxicology and Environmental Health. Part a·Kari Mette MurvollJanneche Utne Skaare
Nov 19, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Donna W LeeLisa A Opanashuk
Jul 4, 2012·Reproductive Biology and Endocrinology : RB&E·Ashok AgarwalSajal Gupta
Dec 8, 2006·Environmental Pollution·James C W LamPaul K S Lam
Jun 25, 2002·Toxicology and Applied Pharmacology·Bernhard HennigLarry W Robertson
Jul 6, 2005·Toxicology and Applied Pharmacology·Jouko Tuomisto
May 1, 2007·The Science of the Total Environment·Kari Mette MurvollBjorn Munro Jenssen
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Feb 1, 1997·Environmental Health Perspectives·G A LeBlanc, L J Bain
Jul 25, 2019·Oncogene·Yanhong ZhangXinbin Chen
May 23, 2002·International Journal of Hygiene and Environmental Health·Bernhard HennigLarry W Robertson

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