PMID: 11918562Mar 29, 2002Paper

Syngeneic stem cell transplant for spent-phase polycythaemia vera: eradication of myelofibrosis and restoration of normal haematopoiesis

British Journal of Haematology
Shambavi RichardSteven Fruchtman

Abstract

We report a patient with spent-phase polycythaemia vera (S-PV) and massive splenomegaly who failed to engraft after a syngeneic granulocyte colony-stimulating factor-primed peripheral blood stem cell transplant (SCT), but later engrafted after splenectomy. Bone marrow (BM) showed resolution of myelofibrosis (MF) and absent endogenous erythroid colonies. This case demonstrated that (1) normal haematopoiesis can be restored after syngeneic SCT despite extensive MF, and (2) fibrosis can regress following a total body irradiation-containing regimen and syngeneic SCT. As a graft-versus-BM stroma effect is non-existent in syngeneic transplants, there may be a role for autologous SCT to obliterate MF in S-PV.

References

Dec 1, 1992·British Journal of Haematology·G J CreemersA Hagenbeek
Jan 1, 1990·European Journal of Haematology·E LöfvenbergA Ost

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Citations

Feb 1, 2007·Current Hematologic Malignancy Reports·William J HoganAyalew Tefferi
Oct 17, 2003·Hematology/oncology Clinics of North America·Alan S Wayne, A J Barrett
Mar 28, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Karen K BallenWael Saber

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