Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses

Biochemical and Biophysical Research Communications
Wei WangYanggu Shi

Abstract

We have identified and characterized a novel single span transmembrane leucine-rich repeat protein, synleurin, that renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS). The major part of the extracellular domain consists of a leucine-rich repeats (LRR) cassette. The LRR central core has 12 analogous LRR repeating modules arranged in a seamless tandem array. The LRRs are most homologous to that of chondroadherin, insulin-like growth factor binding proteins, platelet glycoprotein V, slits, and toll-like receptors. Synleurin expression was detected at low levels in many tissues, including smooth muscle, brain, uterus, pancreas, cartilage, adipose, spleen, and testis. When synleurin is ecotopically expressed in transfected cells, the cells exhibit amplified responses to bFGF, EGF, PDGF-B, IGF-1, IGF-2, and LPS. Synleurin gene (slrn) maps to human chromosome at 5q12. The name synleurin reflects its synergistic effect on cytokine stimulation and its prominent leucine-rich repeats.

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Jul 24, 2020·Nature·David JebbEmma C Teeling
Aug 28, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan CarpenterLuke A J O'Neill
Dec 29, 2020·Frontiers in Cellular and Infection Microbiology·Emily Clayton, Muhammad Munir
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