PMID: 9419223Mar 7, 1998Paper

Synonymous and nonsynonymous substitutions in mammalian genes: intragenic correlations

Journal of Molecular Evolution
F Alvarez-ValinG Bernardi

Abstract

Previous investigations indicated that synonymous and nonsynonymous substitution rates are correlated in mammalian genes. In the present work, this correlation has been studied at the intragenic level using a dataset of 48 orthologous genes from species belonging to at least four different mammalian orders. The results obtained show that the intragenic variability in synonymous rates is correlated with that of nonsynonymous rates. Moreover, the variation in GC level (and especially of C level) of silent positions along each gene is correlated with the variation in synonymous rate. These results reinforce the previous conclusions that synonymous and nonsynonymous rates as well as GC levels of silent positions are to some extent under common selective constraints.

Citations

Mar 21, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L H Caporale
Apr 6, 2004·Molecular Phylogenetics and Evolution·Fernando Alvarez-ValinGiorgio Bernardi
Feb 15, 2001·Trends in Genetics : TIG·L D Hurst, C Pál
Nov 8, 2003·Gene·Kamel JabbariGiorgio Bernardi
Jan 23, 1999·Current Opinion in Genetics & Development·H Akashi, A Eyre-Walker
Mar 11, 2011·Molecular Biology and Evolution·Liang Yang, Brandon S Gaut
Oct 19, 2001·Molecular Biology and Evolution·H MontellH Ellegren
Mar 21, 2000·Molecular Biology and Evolution·J D HolbrookC J Danpure
Jul 23, 1999·Annals of the New York Academy of Sciences·G D'OnofrioG Bernardi
Sep 30, 2010·Evolution; International Journal of Organic Evolution·Göran ArnqvistDavid J Hosken
Dec 2, 1998·Genetics·N Galtier, D Mouchiroud
Aug 5, 2000·Genetics·A K Fridolfsson, H Ellegren

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