Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Barbara TolussoGianfranco Ferraccioli

Abstract

B cells have acquired an important role in the pathogenesis of rheumatoid arthritis (RA) since B cell depletion allowed to rescue patients poorly responders to TNFalpha blockers. This study focused on the involvement of ZAP-70 as a bio-marker of B cells immune activation in RA. ZAP-70 expression in synovial fluid (SF) B cells obtained from RA patients was increased compared to SF B cells of osteoarthritis (OA) patients. Moreover we found that ZAP-70 positive/CD38 positive and ZAP-70 positive/CD5 positive B cells were enriched in SF. The analysis of B cell apoptosis in vitro showed that the percentage of ZAP-70 negative B cells spontaneously undergoing apoptosis was significantly higher than ZAP-70 positive B cells. The ZAP-70 positive B cell ratio (SF/peripheral blood (PB)) showed a positive correlation with SF autoantibody levels and with local levels of BAFF and IL6. ZAP-70 positive B cells seem to define a subset characterized by increased survival and high relationship with local inflammation and autoimmunity.

References

May 2, 2003·The New England Journal of Medicine·Marta CrespoEmili Montserrat
Jan 17, 2004·Lancet·Jenny A OrchardDavid G Oscier
Aug 15, 2006·Cytometry. Part B, Clinical Cytometry·Marie Christine Béné
Sep 19, 2006·Best Practice & Research. Clinical Rheumatology·J C W EdwardsM J Leandro
Mar 14, 2007·Arthritis Research & Therapy·Claudia Mauri, Michael R Ehrenstein
May 1, 2007·Arthritis and Rheumatism·Axel FinckhUNKNOWN Physicians of the Swiss Clinical Quality Management Program for Rheumatoid Arthritis
Nov 16, 2007·Arthritis Research & Therapy·Miguel Otero, Mary B Goldring

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Citations

Nov 2, 2011·Internal and Emergency Medicine·Gianfranco Ferraccioli, Elisa Gremese
Dec 24, 2013·Antioxidants & Redox Signaling·Elena OrtonaMarina Pierdominici
Feb 6, 2010·Seminars in Immunopathology·Alain FischerClaire Hivroz
Sep 5, 2014·BMC Immunology·Anna Laura FedeleGianfranco Ferraccioli
Sep 18, 2012·The Journal of Rheumatology·Elisa GremeseGianfranco Ferraccioli

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