Synovial cellular and molecular markers in rheumatoid arthritis

Seminars in Immunopathology
M Asif AminJeffrey H Ruth

Abstract

The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, with extensive infiltration of lymphocytes and myeloid cells. Concurrently, the fibroblast-like synoviocytes undergo massive hyperplasia and acquire a tissue-invasive phenotype. In this review, we summarize key components of these processes, focusing on recently-described roles of selected molecular markers of these cellular components of RA synovitis.

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Citations

Sep 12, 2018·Journal of Biophotonics·Lúcia Mara J Dos AnjosJacy Gameiro
Aug 11, 2018·Orthopaedic Surgery·Xiang-Hong MengYong-Cheng Hu
Feb 11, 2020·Frontiers in Pharmacology·Carmen Corciulo, Bruce N Cronstein
Aug 24, 2017·Journal of Cellular Physiology·Palani Dinesh, Mahaboobkhan Rasool
May 17, 2018·Nature Communications·Rizi AiGary S Firestein
Aug 20, 2020·The Journal of Pharmacy and Pharmacology·Shareen SinghSonia Dhiman
Nov 7, 2019·Therapeutic Advances in Chronic Disease·Robert BraggSadanand Fulzele
Jun 24, 2017·Seminars in Immunopathology·Paul Hasler, Cem Gabay
Apr 10, 2019·Current Rheumatology Reviews·Yulia V PolyakovaIrina A Zborovskaya
Apr 28, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Xuling LuoZhiwei Chen
Mar 4, 2019·Biochemical Pharmacology·Charles J Malemud
Jul 27, 2021·The Journal of International Medical Research·Kun GaoDayu Chen
Aug 26, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hiroshi Katayama
Aug 19, 2020·ACS Applied Materials & Interfaces·Jun-Young ParkDongwoo Khang

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Methods Mentioned

BETA
leukapheresis
flow cytometry

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