Synovial chemokine expression and relationship with knee symptoms in patients with meniscal tears

Osteoarthritis and Cartilage
Anjali NairCarla R Scanzello

Abstract

In patients with knee OA, synovitis is associated with knee pain and symptoms. We previously identified synovial mRNA expression of a set of chemokines (CCL19, IL-8, CCL5, XCL-1, CCR7) associated with synovitis in patients with meniscal tears but without radiographic OA. CCL19 and CCR7 were also associated with knee symptoms. This study sought to validate expression of these chemokines and association with knee symptoms in more typical patients presenting for meniscal arthroscopy, many who have pre-existing OA. Synovial fluid (SF) and biopsies were collected from patients undergoing meniscal arthroscopy. Synovial mRNA expression was measured using quantitative RT-PCR. The Knee Injury and Osteoarthritis Outcome Score (KOOS) was administered preoperatively. Regression analyses determined if associations between chemokine mRNA levels and KOOS scores were independent of other factors including radiographic OA. CCL19 in SF was measured by ELISA, and compared to patients with advanced knee OA and asymptomatic organ donors. 90% of patients had intra-operative evidence of early cartilage degeneration. CCL19, IL-8, CCL5, XCL1, CCR7 transcripts were detected in all patients. Synovial CCL19 mRNA levels independently correlated with KOOS A...Continue Reading

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Citations

Nov 4, 2015·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Vanessa G CuéllarEric J Strauss
Nov 4, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carla R Scanzello
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Aug 3, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nisha SambamurthyCarla R Scanzello
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Dec 22, 2019·Osteoarthritis and Cartilage·R J MillerR E Miller
Aug 17, 2021·JBJS Reviews·Danielle H MarkusEric J Strauss

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