Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor

Arthritis Research & Therapy
Sofia ErnestamAnn-Kristin Ulfgren

Abstract

Blockade of tumour necrosis factor (TNF) is an effective treatment in rheumatoid arthritis (RA), but both non-responders and partial responders are quite frequent. This suggests that other pro-inflammatory cytokines may be of importance in the pathogenesis of RA and as possible targets for therapy. In this study we investigated the effect of TNF blockade (infliximab) on the synovial expression of IL-15 in RA in relation to different cell types and expression of other cytokines, to elucidate whether or not IL-15 is a possible target for therapy, independently of TNF blockade. Two arthroscopies with multiple biopsies were performed on nine patients with RA and knee-joint synovitis before and after three infusions of infliximab (3 mg/kg). Synovial biopsies were analysed with immunohistochemistry for expression of IL-15, TNF, IL-1alpha, IL-1ss and IFN-gamma, and for the cell surface markers CD3, CD68 and CD163. Stained synovial biopsy sections were evaluated by computerized image analysis. IL-15 expression was detected in all synovial biopsies taken at baseline. After infliximab therapy, the expression of IL-15 was increased in four patients and reduced in five. Synovial expression of IL-15 was not correlated with any CD marker or ...Continue Reading

References

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Sep 6, 2005·Arthritis and Rheumatism·Bo BaslundIain B McInnes

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Citations

Dec 1, 2006·Arthritis Research & Therapy·Johan LindbergJoakim Lundeberg
Mar 7, 2009·Arthritis Research & Therapy·Ravi C DwivediHani S El-Gabalawy
Jul 14, 2012·PloS One·Marta Benito-MiguelMaría-Eugenia Miranda-Carús
May 17, 2008·Scandinavian Journal of Immunology·A K AnderssonF M Brennan
Jul 30, 2021·International Journal of Rheumatic Diseases·Robert W Ike, Kenneth C Kalunian

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Methods Mentioned

BETA
biopsies
biopsy

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