Synoviorthesis in haemophilia patients with inhibitors

Haemophilia : the Official Journal of the World Federation of Hemophilia
G PastaL Solimeno

Abstract

Recurrent bleeding into joints represents the clinical hallmark of haemophilia and, if not adequately treated, it may cause chronic synovitis and degenerative arthropathy. In haemophilia patients with inhibitors, a more severe degree of synovitis is often observed owing to the fact that treatment is more problematic in this setting. The first treatment option of recurrent haemarthroses and/or chronic synovitis is represented by synoviorthesis, both chemical and radioisotopic, with a success rate of approximately 80% for both. However, radioisotopic synoviorthesis should be preferred in inhibitor patients because it makes it possible to obtain complete synovial fibrosis usually in one session, without the need for repeated injections, thus reducing the risk of bleeding complications and concentrate consumption. For all these reasons this procedure should be implemented and supported, particularly in developing countries.

References

Feb 17, 1979·British Medical Journal·A AronstamM J Painter
Apr 1, 1994·The Journal of Bone and Joint Surgery. American Volume·G E RivardD Marton
Jul 1, 1996·Clinical Orthopaedics and Related Research·F Fernandez-PalazziR Viso
Jul 1, 1996·Clinical Orthopaedics and Related Research·W J Ribbans, A M Phillips
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·H CavigliaR Perez-Bianco
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·F Fernandez-Palazzi
Apr 24, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·P MolhoY Sultan
Aug 12, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·I ScharrerO Neutzling
Jun 9, 2001·The New England Journal of Medicine·P M Mannucci, E G Tuddenham
Feb 1, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·P RadossiG Tagariello
Sep 27, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanH Caviglia
Apr 17, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoA A Jabbar
Jun 3, 2004·Blood·Narine HakobyanLeonard A Valentino
Sep 24, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-Merchan, A Rocino
Jun 28, 2005·Journal of Thrombosis and Haemostasis : JTH·A L DunnT C Abshire
May 13, 2006·Seminars in Hematology·Cindy A Leissinger
Aug 10, 2007·The New England Journal of Medicine·Marilyn J Manco-JohnsonBruce L Evatt
Oct 18, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanM Quintana
Dec 6, 2007·Eye & Contact Lens·Deborah F Sweeney, Thomas J Naduvilath

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Citations

Feb 15, 2013·Nuclear Medicine Communications·Petr TeysslerVladimir Bobek
Aug 25, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·S ThomasUNKNOWN Brazilian Hemophilia Centers
Aug 5, 2021·Experimental and Therapeutic Medicine·Oana Viola BadulescuManuela Ciocoiu

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