Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis

The Journal of Clinical Investigation
J L FunkD E Yocum

Abstract

Proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 (IL-1), mediate the joint destruction that characterizes rheumatoid arthritis (RA). Previous studies have shown that parathyroid hormone-related protein (PTHrP) is a member of the cascade of proinflammatory cytokines induced in parenchymal organs during lethal endotoxemia. To test the hypothesis that NH2-terminal PTHrP, a potent bone resorbing agent, could also be a member of the synovial cascade of tissue-destructive cytokines whose expression is induced in RA, PTHrP expression was examined in synovium and synoviocytes obtained from patients with RA and osteoarthritis (OA). PTHrP production, as determined by measurement of immunoreactive PTHrP(1-86) in tissue explant supernatants, was increased 10-fold in RA versus OA synovial tissue. Synovial lining cells and fibroblast-like cells within the pannus expressed both PTHrP and the PTH/PTHrP receptor, findings that were confirmed by in vitro studies of cultured synoviocytes. TNF-alpha and IL-1beta stimulated PTHrP expression in synoviocytes, while dexamethasone and interferon-gamma, agents with some therapeutic efficacy in the treatment of RA, inhibited PTHrP release. Treatment of synoviocytes with ...Continue Reading

References

Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J M DayerD R Robinson
May 19, 1978·Science·D E WoolleyC E Brinckerhoff
May 3, 1990·The New England Journal of Medicine·E D Harris
Aug 1, 1989·Cellular Immunology·D E YocumP Scuderi
Jun 1, 1989·Journal of Autoimmunity·F M BrennanM Feldmann
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M A ThiedeG A Rodan
Sep 1, 1995·The Journal of Clinical Investigation·G S FiresteinN J Zvaifler
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·L C TetlowD E Woolley
Jul 1, 1994·Journal of Cellular Biochemistry·N C PartridgeA T Pearman
Dec 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L G Raisz
Sep 1, 1995·Calcified Tissue International·T TsukazakiS Yamashita
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
May 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H KohnoT Nakamura
Jul 17, 1997·The New England Journal of Medicine·G S Firestein, N J Zvaifler

❮ Previous
Next ❯

Citations

Oct 19, 2000·Arthritis and Rheumatism·E M Gravallese, S R Goldring
Jan 13, 2006·Rheumatology International·Peter OelznerGert Hein
Sep 4, 2009·Genes & Nutrition·Yuusuke SekiguchiMasahiro Wada
May 3, 2003·Biochimica Et Biophysica Acta·Maria Cristina AisaDario Maggio
May 5, 2010·Nature Reviews. Rheumatology·Laurence Morel
Sep 16, 2000·Current Opinion in Rheumatology·G C TsokosM P Nambiar
Sep 16, 2000·Current Opinion in Rheumatology·Z AmouraJ C Piette
Jul 16, 2002·Current Opinion in Rheumatology·Steven R Goldring
May 9, 2001·Current Opinion in Nephrology and Hypertension·Y S Yim, E K Wakeland
Aug 12, 2005·Current Opinion in Rheumatology·Harini Bagavant, Shu Man Fu
Oct 29, 2000·Annals of the Rheumatic Diseases·S R Goldring
Sep 5, 2002·The Journal of Clinical Investigation·Masaki Inada, Stephen M Krane
Nov 30, 2000·Arthritis Research·S R Goldring, E M Gravallese
May 16, 2002·Current Rheumatology Reports·Steven R Goldring, Ellen M Gravallese
Apr 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G HilalD Lajeunesse
Jun 22, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P E Di CesareC S Carlson
Oct 3, 2002·Biochemical and Biophysical Research Communications·J L FunkW Carley
Jan 15, 2005·Biochemical and Biophysical Research Communications·Takaaki MatayoshiTetsu Takahashi
May 9, 2015·Mediators of Inflammation·Piero RuscittiRoberto Giacomelli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.