SYNTAX-justified trend toward restricting coronary artery bypass grafting to more serious cases

General Thoracic and Cardiovascular Surgery
Mamoru ArakawaHideo Adachi

Abstract

Since drug-eluting stents (DESs) appeared in Japan, coronary artery bypass grafting (CABG) has been indicated for more severe lesions. To understand the implications of this trend, we compared SYNTAX scores in two groups of patients treated with CABG before and after DESs approval. Consecutive CABG patients during January 2001-July 2003 (pre-DES era patients, n = 160) and January 2008-July 2010 (DES era patients, n = 103) were included. The SYNTAX scores of both groups were compared and a cardiologist retrospectively re-evaluated coronary angiograms to determine whether CABG or percutaneous coronary intervention (PCI) would be recommended under current standards. SYNTAX scores were significantly higher in DES era group compared with pre-DES era group (33.3 ± 10.6 vs. 28.1 ± 10.6, p < 0.01). Percutaneous coronary intervention would be the preferred treatment option in 66 (41 %) of pre-DES patients, whose SYNTAX scores were significantly lower than those of patients who were considered good candidates for CABG (21.9 ± 9.3 vs. 32.5 ± 9.1, p < 0.01). Although CABG is now being performed in intermediate-to-highly complex cases, DES era outcomes, including operative mortality and early graft failure, have not worsened in comparison t...Continue Reading

References

Apr 25, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·H J GeisslerE R de Vivie
Oct 5, 2005·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Teruhisa KazuiUNKNOWN Japanese Association for Thoracic Surgery Committee of Science
Nov 25, 2005·The Annals of Thoracic Surgery·Itzhak HerzRephael Mohr
Mar 28, 2006·The Annals of Thoracic Surgery·John R LiddicoatFrank Sellke
Sep 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN Japanese Coronary Artery Disease (JCAD) Study Investigators
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Shinji KanemitsuToshihiko Kinoshita
Oct 9, 2007·Current Opinion in Cardiology·Pallav Garg, Laura Mauri
Jan 25, 2008·The New England Journal of Medicine·Edward L HannanRobert H Jones
Feb 21, 2009·The New England Journal of Medicine·Patrick W SerruysUNKNOWN SYNTAX Investigators
Apr 28, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Umberto BenedettoRiccardo Sinatra
Jun 8, 2010·European Heart Journal·William Wijns, Philippe H Kolh
Jun 22, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiromasa HoriguchiShinya Matsuda
Aug 31, 2010·European Heart Journal·UNKNOWN Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for CardDavid Taggart
Nov 6, 2012·Circulation·Akira MaruiUNKNOWN CREDO-Kyoto Investigators
May 10, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group

❮ Previous
Next ❯

Citations

Jun 24, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Satoshi ItohAtsushi Yamaguchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.