Syntaxin 6: A novel predictive and prognostic biomarker in papillary renal cell carcinoma

Scientific Reports
Taylor C PeakGagan Deep

Abstract

Syntaxin 6 is a SNARE family protein known to play an important role in intracellular trafficking. Here, we examined the tumorogenic role of syntaxin 6 in renal cell carcinoma (RCC). The Cancer Genome Atlas (TCGA) was queried for clinicopathologic data and syntaxin 6 expression. We found a significant difference in overall survival (OS) between groups, with high syntaxin 6 expression correlating with decreased survival. When stratifying the data based on histological subtype, the papillary RCC subtype exhibited a significant correlation between syntaxin 6 expression and survival. Using ROC curve, we calculated the area under the curve (AUC) to determine the ability of syntaxin 6 to predict 3-year overall survival. The AUC for syntaxin 6 was 0.73, significantly higher compared to 0.52 for T stage. Next, syntaxin 6 expression was evaluated in clear cell (786-O and Caki-1) and papillary (Caki-2 and ACHN) RCC cells. Syntaxin 6 expression was higher in Caki-1 and ACHN RCC cells. Silencing of syntaxin 6 in ACHN cells significantly decreased the cell viability (p < 0.001). Overall, syntaxin 6 could be a prognostic biomarker for patients with papillary RCC and syntaxin 6 inhibitors hold promise as a novel therapy against RCC.

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Citations

Apr 24, 2020·The Tohoku Journal of Experimental Medicine·Xiaomin WangDongyuan Zhu
Nov 2, 2019·Molecular Carcinogenesis·Taylor C PeakGagan Deep
Oct 12, 2019·Nature Reviews. Urology·Anna BrodziakAnna M Czarnecka
Apr 2, 2021·Frontiers in Oncology·Keying ZhangWeijun Qin

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Methods Mentioned

BETA
ubiquitination
PCR
electrophoresis

Software Mentioned

UALCAN
SPSS Statistics®
GraphPad Prism

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