Syntheses and antifungal activity of dl-griseofulvin and its congeners. III

Chemical & Pharmaceutical Bulletin
Y TakeuchiT Harayama

Abstract

Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a) = 1d > 1b, c > 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.

Citations

Apr 2, 2005·Chemical & Pharmaceutical Bulletin·Teppei KumemuraSatoshi Hibino
Dec 6, 2014·Chemical Reviews·Asger B PetersenMads H Clausen

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.