PMID: 6103953May 1, 1980Paper

Syntheses and evaluation of ketals, hemithioketals, and dithioketals of conjugated styryl ketones principally for antineoplastic activity

Journal of Pharmaceutical Sciences
J R Dimmock, L M Smith

Abstract

Ketals, hemithioketals, and dithioketals of nuclear-substituted styryl ketones were prepared as latentiated forms of the ketones. This undertaking was based on the premise that there is increased acidity in tumors compared to normal tissue, and thus preferential regeneration of the ketone in neoplastic tissue may occur. Attempts to form 1,3-dioxolans of Mannich bases were unsuccessful. The prepared compounds did not possess significant anticancer properties, but analgesic, antiinflammatory, antihistaminic, and antimicrobial activities were found in the prepared Mannich bases.

References

Dec 1, 1976·Journal of Cellular Physiology·E Racker
Jul 1, 1977·Journal of Pharmaceutical Sciences·M J KornetJ H Thorstenson
Jun 1, 1969·Journal of Pharmaceutical Sciences·J H BillmanR May
Sep 1, 1966·Journal of Medicinal Chemistry·Z B PapanastassiouP L Levins
Jul 1, 1962·Biochemical Pharmacology·Y F SHEALYW R LASTER
Jan 29, 1965·Science·M H Lepper, D Perlman

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Citations

Feb 14, 2002·European Journal of Medicinal Chemistry·Jonathan R DimmockJames P Stables
May 14, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Halis SuleymanMehmet Asoglu
May 1, 1992·Journal of Pharmaceutical Sciences·J R DimmockH A Semple
Dec 1, 1986·Environmental Health Perspectives·J E CoggleS R Moores

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