Syntheses and Immunological Evaluation of Self-Adjuvanting Clustered N-Acetyl and N-Propionyl Sialyl-Tn Combined with a T-helper Cell Epitope as Antitumor Vaccine Candidates

Angewandte Chemie
Tsung-Che ChangKoichi Fukase

Abstract

Sialyl-Tn (STn) is a tumor-associated carbohydrate antigen (TACA) rarely observed on healthy tissues. We synthesized two fully synthetic N-acetyl and N-propionyl STn trimer (triSTn) vaccines possessing a T-helper epitope and a TLR2 agonist, since the clustered STn antigens are highly expressed on many cancer cells. Immunization of both vaccines in mice induced the anti-triSTn IgG antibodies, which recognized triSTn-expressing cell lines PANC-1 and HepG2. The N-propionyl triSTn vaccine induced the triSTn-specific IgGs, while IgGs induced by the N-acetyl triSTn vaccine were less specific. These results illustrated that N-propionyl triSTn is a valuable unnatural TACA for anticancer vaccines.

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Citations

Jul 4, 2019·Glycoconjugate Journal·Chengcheng SongYifa Zhou
Oct 9, 2019·Chemistry, an Asian Journal·Qi FengKoichi Fukase
Dec 10, 2019·MedChemComm·Pablo ValverdeAna Gimeno
Aug 3, 2021·Chemical Reviews·Lu SuGuosong Chen
Sep 12, 2020·Chemical Reviews·Wen-Hao Li, Yan-Mei Li

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