Syntheses and studies of new forms of N-sulfonyloxy β-lactams as potential antibacterial agents and β-lactamase inhibitors

Bioorganic & Medicinal Chemistry
Serena Carosso, Marvin J Miller

Abstract

The synthesis of a small library of N-sulfonyloxy-2-azetidinones is reported and the preliminary results of the investigation of the biological activity of these molecules are discussed. These new multi-electrophilic β-lactams ('electrophilic bombs') display unexpected selectivity in their antibacterial activity and β-lactamase inhibitory activity.

References

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Citations

Jun 16, 2016·Future Medicinal Chemistry·Fernando CoronaJosé L Martínez
Jun 9, 2017·Journal of Medicinal Chemistry·Domenico SchillaciStella Cascioferro
Dec 18, 2020·Expert Opinion on Therapeutic Patents·Katarina GrabrijanStanislav Gobec
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexandra V Krivitskaya, Maria G Khrenova
Jun 21, 2020·Mini Reviews in Medicinal Chemistry·Taíse H O LeiteMarcus Vinícius N de Souza

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