Syntheses, characterization, and biological activity of novel mono- and binuclear transition metal complexes with a hydrazone Schiff base derived from a coumarin derivative and oxalyldihydrazine

Monatshefte für chemie
Esther Theresa KnittlWolfgang Linert

Abstract

A hydrazone Schiff base ligand was synthesized by the condensation of 3-formyl-4-hydroxycoumarin and oxalyldihydrazide in the molar ratio 2:1. The Schiff base ligand acts as a mono-, bi-, tri- or even tetradentate ligand with metal cations in the molar ratios 1:1 or 2:1 (M:L) to yield either mono- or binuclear complexes as keto or enol isomers, whereM = Co(II), Ni(II), Cu(II), VO(IV), and Fe(III). The ligand and its metal complexes were characterized by elemental analyses, IR,1H NMR, mass, and UV-Vis spectroscopy. Furthermore, the magnetic moments were calculated from the measured electric conductivities of the complexes. According to the received data, the dihydrazone ligand contains one or two units of ONO domains and can bind to the metal ions via the azomethine nitrogen, the carbonyl oxygen atoms, and/or the phenolic oxygen atoms. Electronic spectra and the magnetic moments of all complexes show that the complexes' geometries are either octahedral, tetrahedral, square planar, or square pyramidal. Cyclic voltammograms of the mononuclear Co(II) and Ni(II) complexes show quasi-reversible peaks. Tests against two pathogenic bacteria as Gram-positive and Gram-negative bacteria for both, the Schiff base ligand and its metal compl...Continue Reading

References

Dec 8, 2005·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Adel A A Emara, Azza A A Abou-Hussen
Aug 18, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Azza A A Abu-Hussen, Wolfgang Linert
Jul 5, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·A I MosaA A Saddiq
Sep 10, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Puja KapoorR V Singh
May 15, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Azza A A Abou-Hussein, Wolfgang Linert
Dec 22, 2015·Journal of Medicinal Chemistry·Marta FerraroniClaudiu T Supuran
Feb 4, 2016·European Journal of Medicinal Chemistry·Irlan Almeida FreiresPedro Luiz Rosalen

❮ Previous
Next ❯

Methods Mentioned

BETA
ESR

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.