Syntheses of 1beta-methylcarbapenems bearing 5-methyl-4-hydroxypyrrolidinone

Chemical & Pharmaceutical Bulletin
Do Kyu PyunCheol Hae Lee

Abstract

A new series of 1beta-methylcarbapenems 1a-d bearing 5-methyl-4-mercaptopyrrolidinone rings has been prepared and evaluated for in vitro antibacterial activity and pharmacokinetic parameters. Most compounds showed excellent antibacterial activity and high stability to dehydropeptidase-1. We have synthesized optically active 5-methyl-4-hydroxypyrrolidinones from enantiomerically pure aziridine esters.

References

Dec 1, 1979·Journal of Medicinal Chemistry·W J LeanzaB G Christensen
May 1, 1990·The Journal of Antibiotics·M SunagawaM Kato
Aug 1, 1983·The Journal of Antibiotics·T MiyaderaS Sugawara
May 1, 1997·The Journal of Antibiotics·M MiyauchiI Kawamoto

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Citations

Nov 9, 2019·Current Topics in Medicinal Chemistry·Américo J S AlvesTeresa M V D Pinho E Melo
Aug 23, 2019·Beilstein Journal of Organic Chemistry·Iwona E GłowackaDorota G Piotrowska

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