PMID: 7035667Aug 1, 1981Paper

Syntheses of 9-acridine- and 2-phenanthridinemethanols as potential antimalarials

Journal of Medicinal Chemistry
C W MuthH T Chao

Abstract

alpha-(1-Piperidinylmethyl)-9-acridinemethanol (3), alpha-[(dibutylamino)ethyl]-9-acridanmethanol (4a), and alpha-[(dibutylamino)methyl]-2-phenanthridinemethanol (5) have been made and all are ineffective as antimalarials against Plasmodium berghei in mice. 9-Acridinyloxirane showed no significant mutagenicity for strains TA 98 or TA 100 of Salmonella typhimurium.

Citations

Jan 1, 1999·Bioorganic & Medicinal Chemistry Letters·G ZagottoM Palumbo
Apr 14, 1999·Bioorganic & Medicinal Chemistry Letters·M K KunduN Valecha
Sep 13, 2006·Antimicrobial Agents and Chemotherapy·G S DowK S Smith

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