Syntheses of functionalized indium porphyrins for monoclonal antibody labeling

Bioconjugate Chemistry
C H Bedel-CloutourM Pereyre

Abstract

The syntheses and characterizations of five differently hydrosoluble monosubstituted aryl porphyrins are reported. Their metallation with indium-111 was achieved and provided tracers with strong specific activities. The covalent coupling between indium-111 porphyrins and BSA served as a model reaction for the definition of the best experimental coupling conditions; the transposition to the labeling of anti-CEA monoclonal antibody was realized. The conjugates exhibited an in vitro good mAb-labeling efficiency, as well as a good preservation of immunoreactivity.

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Citations

Aug 10, 2001·Journal of Peptide Science : an Official Publication of the European Peptide Society·S De LucaG Morelli
Dec 20, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Philip A Waghorn
Sep 22, 2006·Journal of Photochemistry and Photobiology. B, Biology·Martha Sibrian-VazquezM Graça H Vicente
Aug 29, 2018·Chemical Society Reviews·Verónica Almeida-MarreroAndrés de la Escosura
May 26, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Haiqing WangZheng Yang
Jan 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Christoph M GriessingerManfred Kneilling
Dec 26, 2001·Chemical Reviews·H Ali, J E van Lier

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