PMID: 7581168Jul 1, 1995Paper

Syntheses of several 99mTc and 131I labeled neoglycoalbumins and their differential uptake patterns in animal biodistribution experiments

Nuclear Medicine and Biology
H S SarkarS Banerjee

Abstract

Several glycoconjugates, alpha-D-mannopyranosyl, beta-L-fucopyranosyl, alpha-L-rhamnopyranosyl, beta-D-glucopyranosyl and beta-D-galactopyranosyl human serum albumin, were synthesized using C9-tether and radiolabeled with 99mTc and 131I. Both 99mTc and 131I radiolabeled neoglycoalbumins had considerable stability and exhibited similar biodistribution patterns within the experimental limits. The results of biodistribution studies can be explained from the in vitro observations that 99mTc-beta-D-galactopyranosyl albumin binds to hepatic binding protein in liver in a dose-dependent fashion. The radiolabeled glycoalbumins derived from D-mannopyranose and L-fucopyranose also bind in a dose-dependent fashion to the receptors present in the liver sinusoidal cells and spleen macrophages. The beta-D-glucopyranosyl and alpha-L-rhamnopyranosyl neoglycoalbumins accumulate nonspecifically in liver and spleen.

References

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