Synthesis, acoustic stability, and pharmacologic activities of papaverine-loaded echogenic liposomes for ultrasound controlled drug delivery.

Journal of Liposome Research
Patrick H KeeD D McPherson

Abstract

development of encapsulated therapeutics that could be released upon ultrasound exposure has strong implications for enhancing drug effects at the target site. We have developed echogenic liposomes (ELIP) suitable for ultrasound imaging of blood flow and ultrasound-mediated intravascular drug release. Papaverine was chosen as the test drug because its clinical application requires high concentration in the target vascular bed but low concentration in the systemic circulation. the procedure for preparation of standard ELIP was modified by including Papaverine hydrochloride in the lipid hydration solution, followed by three freeze-thaw cycles to increase encapsulation of the drug. Sizing and encapsulation pharmacokinetics were performed using a Coulter counter and a phosphodiesterase activity assay. Stability of Papaverine-loaded ELIP (PELIP) was monitored with a clinical diagnostic ultrasound scanner equipped with a linear array transducer at a center frequency of 4.5 MHz by assessing the mean digital intensity within a region of interest over time. The stability of PELIP was compared to those of standard ELIP and Optison. relative to standard ELIP, PELIP were larger (median diameter = 1.88 +/- 0.10 microm for PELIP vs 1.08 +/- ...Continue Reading

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Citations

Mar 2, 2013·Expert Opinion on Drug Delivery·Jonathan T SuttonChristy K Holland
Jun 26, 2009·Expert Opinion on Drug Delivery·Hui Wang, Xiaoyuan Chen
Feb 13, 2016·Biomicrofluidics·Guillaume LajoinieMichel Versluis
Jan 30, 2013·Ultrasonics Sonochemistry·Jonathan A KopechekChristy K Holland
Nov 11, 2009·Ultrasound in Medicine & Biology·Denise A B SmithChristy K Holland
Aug 8, 2009·Journal of the American College of Cardiology·Shao-Ling HuangDavid D McPherson
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Oct 28, 2009·Journal of Liposome Research·Dariusz ManKrystian Kubica
Jan 19, 2021·ACS Biomaterials Science & Engineering·Rajeet ChandanRinti Banerjee

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