PMID: 11918072Mar 29, 2002Paper

Synthesis and activities of bactobolin derivatives having new functionality at C-3

The Journal of Antibiotics
Hayamitsu AdachiT Takeuchi

Abstract

Some derivatives of bactobolin were prepared from bactobolin (1) by transformation of the dichloromethyl group at C-3 to the hydroxymethyl, carboxylic acid, methanesulfonyloxymethyl and aldehydeoxime groups. The derivatives proved to be less active than the parent antibiotic 1 against bacteria as well as cytotoxicity, indicating that the functionality at C-3 considerably influences the biological activity.

Citations

Apr 15, 2020·Journal of the American Chemical Society·Petra VojáčkováJakub Švenda

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