PMID: 9544940Apr 17, 1998Paper

Synthesis and activities of bactobolin derivatives based on the alteration of the functionality at C-3 position

The Journal of Antibiotics
H AdachiT Takeuchi

Abstract

Some derivatives of bactobolin were prepared from bactobolin (1) by radical reduction and formation of the fused azetidine ring. The derivatives proved less active than the parent antibiotic 1 against bacteria, indicating that dichloromethyl group at C-3 position play an important role in biological activity.

Citations

Apr 15, 2020·Journal of the American Chemical Society·Petra VojáčkováJakub Švenda

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