PMID: 11213289Feb 24, 2001Paper

Synthesis and activity of analogues of SB-219383: novel potent inhibitors of bacterial tyrosyl tRNA synthetase

The Journal of Antibiotics
J M BergeStephen Rittenhouse

Abstract

SB-219383 is a naturally occurring antibiotic, which acts by inhibition of tyrosyl tRNA synthetase. Semi-synthetic derivatives of SB-219383 were prepared with the objective of elucidating the key features required for inhibition of tyrosyl tRNA synthetase in order to improve the antibacterial activity. Some ester and amide derivatives as well as monocyclic analogues exhibited sub-nanomolar inhibitory activity against tyrosyl tRNA synthetase.

Citations

Sep 22, 2001·Protein Science : a Publication of the Protein Society·X QiuR L Jarvest
Apr 28, 2007·Expert Opinion on Investigational Drugs·Urs A OchsnerNebojsa Janjic
Jun 17, 2010·Nature Reviews. Microbiology·Katie J SimmonsColin W G Fishwick
Feb 22, 2002·The Journal of Biological Chemistry·Joseph Austin, Eric A First
Mar 31, 2021·Current Microbiology·Jean Parcelli Costa do ValeHélcio Silva Dos Santos
Mar 18, 2008·The Journal of Organic Chemistry·Rajendra S ManeDilip D Dhavale

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