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Synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine

Journal of Medicinal Chemistry

Jan 1, 1976

J G HenkelP H Lewis

PMID: 1536

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Abstract

Crystalline perchlorate salts of aziridinium ions derived from phenoxybenzamine and dibenamine were prepared. Both aziridinium ions were tested on the rat vas deferens and found to possess alpha-adrenergic potencies which were nearly identical with those of the parent compounds. The hyd...read more

Mentioned in this Paper

Vas Deferens Structure
Aziridines
Smooth Muscle
Hydrolysis
Salts
Azirines
Inotropism
Amines
Adrenergic alpha-Antagonists
Cyclization
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Synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine

Journal of Medicinal Chemistry

Jan 1, 1976

J G HenkelP H Lewis

PMID: 1536

DOI:

Abstract

Crystalline perchlorate salts of aziridinium ions derived from phenoxybenzamine and dibenamine were prepared. Both aziridinium ions were tested on the rat vas deferens and found to possess alpha-adrenergic potencies which were nearly identical with those of the parent compounds. The hyd...read more

Mentioned in this Paper

Vas Deferens Structure
Aziridines
Smooth Muscle
Hydrolysis
Salts

Related Papers

Paper Details
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  • References
  • Citations8
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    References currently unavailable

    We're still populating references for this paper, please check back later.

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