Synthesis and analysis of separation networks for the recovery of intracellular chemicals generated from microbial-based conversions

Biotechnology for Biofuels
Kirti M YenkieChristos T Maravelias

Abstract

Bioseparations can contribute to more than 70% in the total production cost of a bio-based chemical, and if the desired chemical is localized intracellularly, there can be additional challenges associated with its recovery. Based on the properties of the desired chemical and other components in the stream, there can be multiple feasible options for product recovery. These options are composed of several alternative technologies, performing similar tasks. The suitability of a technology for a particular chemical depends on (1) its performance parameters, such as separation efficiency; (2) cost or amount of added separating agent; (3) properties of the bioreactor effluent (e.g., biomass titer, product content); and (4) final product specifications. Our goal is to first synthesize alternative separation options and then analyze how technology selection affects the overall process economics. To achieve this, we propose an optimization-based framework that helps in identifying the critical technologies and parameters. We study the separation networks for two representative classes of chemicals based on their properties. The separation network is divided into three stages: cell and product isolation (stage I), product concentration (...Continue Reading

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Citations

Nov 6, 2018·Biotechnology for Biofuels·Wenzhao Wu, Christos T Maravelias
Oct 19, 2019·Biotechnology for Biofuels·Pratik Prashant PawarArvind Mallinath Lali

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Methods Mentioned

BETA
genetic modifications

Software Mentioned

BARON
SOL
SOL SLD
GAMS
SOL LQD
Atpe

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