Synthesis and anti-bacterial activity of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles

European Journal of Medicinal Chemistry
Bobba Venkata Siva KumarRamchandra Bhimrao Mane

Abstract

Synthesis of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles by the condensation of o-phenylenediamine with 6-fluoro-3,4-dihydro-2H-chroman-2-carboxylic acid, and subsequent reactions with different types of electrophiles, have been reported. Some compounds exhibited promising anti-bacterial activity against Salmonella typhimurium; however, they showed poor activity against S. aureus. The biological activity against PDE IV for potential anti-asthamatic effect, and against DP-IV and PTP 1B for potential anti-diabetic effects was disappointing.

References

Jun 13, 2001·International Journal for Parasitology·P Köhler
Jul 20, 2002·Bioorganic & Medicinal Chemistry Letters·Juan ValdezRafael Castillo

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Citations

Jan 22, 2013·European Journal of Medicinal Chemistry·Asif HusainRavinesh Mishra
Aug 8, 2013·Organic and Medicinal Chemistry Letters·Yekkirala VenkateswarluPanuganti Leelavathi
Dec 7, 2014·European Journal of Medicinal Chemistry·Geeta Yadav, Swastika Ganguly
Dec 25, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Jaladi Ashok KumarBhimapaka China Raju
Aug 7, 2019·BMC Chemistry·Sumit TahlanBalasubramanian Narasimhan
May 11, 2019·Journal of Biomolecular Structure & Dynamics·Khalid MahmoodVickie McKee

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