Synthesis and anti-cancer activity of chalcone linked imidazolones

Bioorganic & Medicinal Chemistry Letters
Ahmed KamalManika Pal-Bhadra

Abstract

A series of novel chalcone linked imidazolones were prepared and evaluated for their anti-cancer activity against a panel of 53 human tumour cell lines derived from nine different cancer types: leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate and breast. Some of these hybrids (6, 7 and 8) showed good anti-cancer activity with GI(50) values ranging from 1.26 to 13.9 microM. When breast carcinoma cells (MCF-7) were treated with 10 microM concentration of compounds TMAC, CA-4, 6 and 8 cell cycle arrest was observed in G2/M phase. Surprisingly, the increased concentration of the same compound to 30 microM caused accumulation of cells in G0/G1 phase of the cell cycle.

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Citations

Feb 18, 2012·Journal of Medicinal Chemistry·Michael W RobinsonWilliam A Maltese
Apr 27, 2011·Cancer Cell International·M Janaki RamaiahManika Pal Bhadra
Jan 16, 2013·Expert Opinion on Drug Discovery·Ahmed KamalArutla Viswanath
Feb 22, 2011·European Journal of Medicinal Chemistry·Dorota G PiotrowskaAndrzej E Wróblewski
May 26, 2015·European Journal of Medicinal Chemistry·Debarshi Kar MahapatraVivek Asati
Jan 27, 2015·European Journal of Medicinal Chemistry·Mostafa M GhorabSally S Zahran
May 7, 2016·Chemical & Pharmaceutical Bulletin·Dinesh KumarSubheet Jain
May 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu-Kai SuChien-Min Lin
Aug 20, 2014·European Journal of Medicinal Chemistry·Parvesh SinghVipan Kumar
Mar 5, 2017·Bioorganic & Medicinal Chemistry Letters·Pravin S BhaleBabasaheb P Bandgar
Mar 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Addila Abu BakarSyed Adnan Ali Shah
Mar 23, 2017·Natural Products and Bioprospecting·Xiu-Juan YinJi-Jun Chen
Jul 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·I-Jou TengSy-Jou Chen
Nov 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rimsha IrfanRahman Shah Zaib Saleem
May 11, 2017·Chemical Reviews·Chunlin ZhuangZhenyuan Miao
Nov 28, 2017··Mohammad Abdul BaseerSyed Shah Najib Noorulhaq

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