Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles

Bioorganic & Medicinal Chemistry Letters
Gerhard PürstingerJohan Neyts

Abstract

The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and other enteroviruses at low-micromolar concentrations.

References

Oct 1, 1982·Antimicrobial Agents and Chemotherapy·H L TorneyD L Steward
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Mar 12, 2003·Pharmacotherapy·Naomi R FloreaDavid P Nicolau
Oct 19, 2006·Virology·Rajeshwar P Verma, Corwin Hansch

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Citations

Aug 23, 2011·Journal of the American Chemical Society·William L JorgensenKaren S Anderson

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