PMID: 9648522Jul 2, 1998Paper

Synthesis and antibacterial activities of new carbapenems having a proline reverse amide moiety at the C-2 position

Archiv der Pharmazie
S H HwangK J Lee

Abstract

The synthesis of new 1 beta-methylcarbapenems (1a-l) having a proline reverse amide moiety at the C-2 position and their in vitro antibacterial activities are described. The compounds were evaluated by the Mueller-Hinton agar dilution method and compared with meropenem as control. Aliphatic amides (1a-h) are found to show greater antibacterial activity than aromatic amides (1i-l). Moreover, C-2 free amino compound (1m) reveals greater activity than any other amide compounds (1a-l).

Citations

Feb 15, 2000·Bioorganic & Medicinal Chemistry Letters·Y K KangS W Park
Feb 22, 2014·Organic Letters·Zhe LvGuangxin Liang

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